Pyometra

Associated Terms:

Uterine Infection, Metritis

The term "ACVS Diplomate" refers to a veterinarian who has been board certified in veterinary surgery. Only veterinarians who have successfully completed the certification requirements of the ACVS are Diplomates of the American College of Veterinary Surgeons and have earned the right to be called specialists in veterinary surgery.

Your ACVS board-certified veterinary surgeon completed a three-year residency program, met specific training and caseload requirements, performed research and had research published. This process was supervised by ACVS Diplomates, ensuring consistency in training and adherence to high standards. After completing the residency program, the individual passed a rigorous examination. Only then did your veterinary surgeon earn the title of ACVS Diplomate.

Language: English / Español

Overview:

Pyometra is an infection of the uterus that may occur in dogs and cats making the pet very ill. The uterus is generally filled with pus. Although the disease has been recognized for decades, the true disease process has still not been completely understood. It is generally recognized that progesterone and estrogen and their receptors have a role in the development of pyometra; however, the infection is triggered by bacterial involvement.

The cyclical hormonal influences of the female dog and cat allow the uterus to go through changes that will be acceptable for fertilization of an embryo. If bacteria are introduced into the uterus at a certain time during the cycle, hormonal regulation of the uterus allows the infection to start and become life-threatening. The bacteria typically cultured from the uterus are bacteria that would be found in the areas of the intestines and vagina (E. coli is the most common). Therefore, many of the infections are considered either from an ascending infection from the vagina, a concurrent urinary tract infection, or fecal contamination.

Most dogs and cats that are spayed early in life will not develop pyometra. However, a uterine stump pyometra may occur after incomplete ovariohysterectomy which allows a segment of the uterine body or horn to become infected. Typically, either a portion of the ovarian tissue is still present or the animal has been subjected to progestational hormones to allow this situation to develop.

Signs and Symptoms:

Because the infection can be so severe, the signs your pet may show are not limited to the genital tract. Your pet can become so overwhelmed by the inflammation associated with the infection that the uncontrolled inflammatory process may be life-threatening.

The most common clinical signs in dogs and cats are:

lethargy
depression
anorexia
excessive water intake
excessive urination
pale mucous membranes
bloody vaginal discharge

Vomiting, diarrhea, weight loss, abdominal distension, and inflamed eyes have been reported less frequently. Some pets may have no clinical signs other than purulent vaginal discharge. Pyometra should be considered in any intact female dog that is sick.

Many dogs and cats will have a closed cervix and therefore the obvious sign of bloody vaginal discharge may not be present.

Diagnostics:

Your primary-care veterinarian may suspect the diagnosis based on your history and your pet’s physical exam. If the cervix is not open, the diagnosis may take a few more diagnostic tests. In general, a fluid distended uterus is needed to diagnose pyometra. Your veterinarian will likely recommend the following diagnostic tests to help diagnose pyometra:

general chemistry profile
complete blood count
urinalysis
abdominal radiographs
abdominal ultrasound
vaginal cytology

Radiographs are typically very suggestive but abdominal ultrasounds will typically identify the fluid filled uterus (Figure 1).

Treatment:

Pyometra is a medical emergency that requires rapid intervention to prevent overwhelming infection and death. For most pets, preoperative stabilization and resuscitation are first and foremost. After appropriate stabilization, ovariohysterectomy (spay) is the therapy of choice. The results of this therapy are generally a rapid recovery with minimal risk of recurrence. Ovariohysterectomy also negates the risk of ovarian and uterine cancer and future unwanted pregnancy.

Although surgery is the therapy of choice, very special case selection meeting certain criteria may allow valuable breeding animals to be treated medically. However, in addition to the previously mentioned multiple organ problems, the dogs will generally exhibit abdominal pain, excessive vomiting/ defecation, high heart rates, salivation, breathing difficulties, panting, and fever with medical management. It takes several days until an effect is seen when treating pets with pyometra with injectable prostaglandins and antibiotics. Dogs and cats are susceptible to developing pyometra again after medical treatment and should have an ovariohysterectomy performed when their breeding purposes are finished.

Aftercare and Outcome:

Once your pet is discharged from the hospital, the aftercare is minimal. The care is generally the same as it would be for a routine spay; however, your pet will be on antibiotics as prescribed by your veterinarian for at least 10 days. The animal should not be allowed have normal play, stairs, or any off-leash activities for the first two weeks after surgery, and the incision should be protected from self-trauma.

The prognosis for survival with ovariohysterectomy can be as high as 80–100% if abdominal contamination is avoided and the systemic infection is treated and responds appropriately. However, if severe sepsis and organ failure develops, the prognosis can be less favorable. Rare pets may have persistently increased urination and water intake and a state of permanent kidney damage.

Content Theme:

Animal Owners

Also known as:

Pyometra

Uterine Infection

Metritis

This Animal Health Topic was written by and reviewed by Diplomates of the American College of Veterinary Surgeons. Any opinions stated in this article are not necessarily the official position of the American College of Veterinary Surgeons.

The American College of Veterinary Surgeons recommends contacting an ACVS board-certified veterinary surgeon or your general veterinarian for more information about this topic.

To find an ACVS Diplomate, visit www.acvs.org/find-a-surgeon.

Small Animal Health Topic Feedback Form

Your feedback helps us make the Animal Health topics serve you better. Please note that submissions to this form are not monitored by a board-certified surgeon. For questions about your animal's specific condition, please contact an ACVS board-certified surgeon in your area.