Anal sacs are paired small pouches located on either side of the anal opening in dogs, cats, ferrets and other animals. The lining of the sacs produces a smelly brown liquid that is usually eliminated in small quantities during defecation. The purpose of the anal sac is unknown but it is thought that they function in communication about the animal or its territory.
Anal sacs can become inflamed, infected, or impacted (blocked). With these conditions it is common for your pet to scoot its bottom on the ground and lick or chew at the area.
Tumors of the anal sacs (apocrine gland adenocarcinoma is the most common tumor type) are a serious but uncommon problem because they tend to invade surrounding tissues and metastasize (spread to distant tissues) even when the primary tumor is very small. The tumors are almost always only on one side. In approximately 25% of cases, the tumor can cause hypercalcemia (elevated blood calcium) which can cause kidney failure.
Anal sac tumors occur in male and female dogs with roughly an equal incidence. They occur in any breed but are more common in Spaniel breeds. Ten years is the average age of affected dogs. Anal sac tumors are very rare in cats.
The signs of anal sac tumors can be variable:
- an external swelling in the perianal region (Figure 1)
- a mass may be felt during a routine rectal examination
- pain or straining to defecate
- blood in the stool
- excessive thirst and urination may occur if kidney failure is present from elevated calcium levels
- without enlarged lymph nodes (in the abdomen), even a large tumor often produces limited symptoms associated with defecation
Animal owners may observe symptoms of kidney failure from the elevated calcium (referred to as hypercalcemia of malignacy).
These symptoms generally include:
- increased thirst
- increase in urination
- loss of appetite
- lethargy (weakness/tiredness)
In general, the following tests are recommended to diagnose the tumor, provide a clear clinical picture of overall health and evaluate for metastasis:
- Aspiration: A small needle is inserted into the tumor to obtain a few cells that can differentiate cancer from infection or inflammation.
- Blood tests: Assess overall health. Evaluating for hypercalcemia and kidney failure
- Chest x-rays: Evaluate for metastatic nodules and other heart and lung problems
- Abdominal ultrasound: Examination to evaluate for enlarged lymph nodes or tumor spread into other organs such as liver, kidneys, etc. These enlarged lymph nodes are often what produce symptoms associated with defecation.
Most animals are discharged 1-2 days after surgery. There is usually a follow-up appointment to see how your dog is doing and to remove skin sutures or staples (if present). Pain can be well-controlled with owner-administered medications.
Restrictions following surgery usually are:
- use of a restrictive collar for 10-14 days after surgery to prevent the natural tendency of dogs to lick and chew at a wound. This can cause breakdown of the wound and infection.
- stool softening medications may be needed until swelling resolves
- limited and restricted activity is indicated for about 2 weeks to allow recovery and incision healing
Postoperative complications can include:
- incision infection
- wound breakdown (dehiscence)
- fecal incontinence can occur in up to 33% of dogs especially with removal of larger masses. This is usually temporary but owners need to be aware of this problem. If the tumor is only on one side, the incontinence is typically partial in that the dog has difficulty controlling bowel movements but not continuous dropping of stool
- continued kidney problems
The prognosis with apocrine gland adenocarcinoma depends on type of treatment, size of mass, presence of hypercalcemia and presence of lymph node involvement. Surgical removal of these nodes can produce long-term relief of constipation. Some animals have had multiple surgeries to remove recurrent lymph nodes to alleviate obstructions successfully.
It is important that your veterinarian examine the anal sacs as part of your dog’s routine examination. Early detection can greatly improve survival.